hemoglobin f การใช้

• Elevated Hemoglobin F levels are also associated with Leukemia and myeloproliferative disorders.
• Another example are the globin genes which hemoglobin F ) are paralogs of each other.
• "' Hemoglobin F "'is the primary hemoglobin produced by the fetus.
• Hemoglobin F frequently increases in individuals with sickle cell anemia and sickle cell-beta thalassemia.
• This is a group of disorders where the Hemoglobin F is increased without signs or clinical features of thalassemia.
• While each of these proteins serves the same basic function of oxygen transport, they have already diverged slightly in function : fetal hemoglobin ( hemoglobin F ) has a higher affinity for oxygen than adult hemoglobin.
• Due to its relative stability compared to hemoglobin Gower 1 and hemoglobin S, it has been proposed as a subject for reactivation in the adult in cases of severe hemoglobinopathies in subjects for which the reactivation of hemoglobin F is contraindicated due to toxicity concerns.
• It was found to be vitally important for embryonic erythropoiesis in promoting the switch from fetal hemoglobin ( Hemoglobin F ) to adult hemoglobin ( Hemoglobin A ) gene expression by binding to highly conserved CACCC domains . " EKLF " ? + thalassemia in humans.
• A fetus, receiving oxygen via the placenta, is exposed to much lower oxygen pressures ( about 21 % of the level found in an adult's lungs ), so fetuses produce another form of hemoglobin with a much higher affinity for oxygen ( hemoglobin F ) to function under these conditions.
• The fetal hemoglobin's reduction in the severity of the disease comes from its ability to inhibit the formation of hemoglobin aggregates within red blood cells which also contain hemoglobin S . Combination therapy with hydroxyurea and recombinant erythropoietin & mdash; rather than treatment with hydroxyurea alone & mdash; has been shown to further elevate hemoglobin F levels and to promote the development of HbF-containing F-cells.
• Some normal hemoglobin types are; Hemoglobin A ( Hb A ), which is 95-98 % of hemoglobin found in adults, Hemoglobin A2 ( Hb A2 ), which is 2-3 % of hemoglobin found in adults, and Hemoglobin F ( Hb F ), which is found in adults up to 2.5 % and is the primary hemoglobin that is produced by the fetus during pregnancy.